It is absolutely terrible, not only does it happen while playing almost every song, it happens while trying to preview them in the music album AND while trying to compose songs. I don't know if this is caused by the absolutely useless and frankly unasked for new music ranking system or not since it's now having to calculated every measure for XP, but with all these new updates, I really hope that it just gets looked at sooner than later and it just doesn't stay a persistant issue.

It really can't be overstated how bad this is...
Personally I can't in good faith upload anything. and I struggle to work on anything because the sound breaks in preview and during play.
I was very disappointed to see that the Global Lab update the 26th did not fix this problem. It's definitely going to be fun to listen to the Spring Breeze concert with every song desyncing. At least it will be fair this time as everyone will be affected by it.

Same, yeesh it seems to have gotten worse over the week, I could get a good synch like 1/4 listens earlier, now its not even 1/10. Something always desyncs at some point seemingly randomly. 

"4/30 notice says:

Major Update Details

• Music Album Note Limit Increased